Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats
Identifieur interne : 000438 ( Main/Exploration ); précédent : 000437; suivant : 000439Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats
Auteurs : Dan Lu [République populaire de Chine] ; Kefang Liu [République populaire de Chine] ; Di Zhang [République populaire de Chine] ; Can Yue [République populaire de Chine] ; Qiong Lu [République populaire de Chine] ; Hao Cheng [République populaire de Chine] ; Liang Wang [République populaire de Chine] ; Yan Chai [République populaire de Chine] ; Jianxun Qi [République populaire de Chine] ; Lin-Fa Wang [Singapour] ; George F. Gao [République populaire de Chine] ; William J. Liu [République populaire de Chine]Source :
- PLoS Biology [ 1544-9173 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Chiroptera, Interactions hôte-pathogène, Virus à ARN.
- physiologie : Antigènes d'histocompatibilité de classe I.
- virologie : Chiroptera.
- Animaux, Présentation d'antigène.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Histocompatibility Antigens Class I.
- immunology : Chiroptera, Host-Pathogen Interactions, RNA Viruses.
- virology : Chiroptera.
- Animals, Antigen Presentation.
Abstract
Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptide presentation features in that the bat-specific 3–amino acid (aa) insertion enables the tight “surface anchoring” of the P1-Asp in pocket A of bat MHC I. As the classical primary anchoring positions, the B and F pockets of Ptal-N*01:01 also show unconventional conformations, which contribute to unusual peptide motifs and distinct peptide presentation. Notably, the features of bat MHC I may be shared by MHC I from various marsupials. Our study sheds light on bat adaptive immunity and may benefit future vaccine development against bat-borne viruses of high impact on humans.
Url:
DOI: 10.1371/journal.pbio.3000436
PubMed: 31498797
PubMed Central: 6752855
Affiliations:
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Le document en format XML
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type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Health Sciences, University of Macau, Macau SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Macau SAR</wicri:regionArea><wicri:noRegion>Macau SAR</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Di" sort="Zhang, Di" uniqKey="Zhang D" first="Di" last="Zhang">Di Zhang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yue, Can" sort="Yue, Can" uniqKey="Yue C" first="Can" last="Yue">Can Yue</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Institute of Biophysics, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Biophysics, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Qiong" sort="Lu, Qiong" uniqKey="Lu Q" first="Qiong" last="Lu">Qiong Lu</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of HIV/AIDS and Sex-transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cheng, Hao" sort="Cheng, Hao" uniqKey="Cheng H" first="Hao" last="Cheng">Hao Cheng</name><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Beijing Institutes of Life Science, University of Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institutes of Life Science, University of Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Liang" sort="Wang, Liang" uniqKey="Wang L" first="Liang" last="Wang">Liang Wang</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chai, Yan" sort="Chai, Yan" uniqKey="Chai Y" first="Yan" last="Chai">Yan Chai</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qi, Jianxun" sort="Qi, Jianxun" uniqKey="Qi J" first="Jianxun" last="Qi">Jianxun Qi</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Programme in Emerging Infectious Diseases, Duke-NUS Medical School</wicri:regionArea><wicri:noRegion>Duke-NUS Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Faculty of Health Sciences, University of Macau, Macau SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Macau SAR</wicri:regionArea><wicri:noRegion>Macau SAR</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Beijing Institutes of Life Science, University of Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Institutes of Life Science, University of Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, William J" sort="Liu, William J" uniqKey="Liu W" first="William J." last="Liu">William J. Liu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Biology</title><idno type="ISSN">1544-9173</idno><idno type="eISSN">1545-7885</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigen Presentation</term><term>Chiroptera (immunology)</term><term>Chiroptera (virology)</term><term>Histocompatibility Antigens Class I (physiology)</term><term>Host-Pathogen Interactions (immunology)</term><term>RNA Viruses (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes d'histocompatibilité de classe I (physiologie)</term><term>Chiroptera (immunologie)</term><term>Chiroptera (virologie)</term><term>Interactions hôte-pathogène (immunologie)</term><term>Présentation d'antigène</term><term>Virus à ARN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Histocompatibility Antigens Class I</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chiroptera</term><term>Interactions hôte-pathogène</term><term>Virus à ARN</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chiroptera</term><term>Host-Pathogen Interactions</term><term>RNA Viruses</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antigen Presentation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Présentation d'antigène</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptide presentation features in that the bat-specific 3–amino acid (aa) insertion enables the tight “surface anchoring” of the P1-Asp in pocket A of bat MHC I. As the classical primary anchoring positions, the B and F pockets of Ptal-N*01:01 also show unconventional conformations, which contribute to unusual peptide motifs and distinct peptide presentation. Notably, the features of bat MHC I may be shared by MHC I from various marsupials. 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George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Liu, Kefang" sort="Liu, Kefang" uniqKey="Liu K" first="Kefang" last="Liu">Kefang Liu</name><name sortKey="Liu, Kefang" sort="Liu, Kefang" uniqKey="Liu K" first="Kefang" last="Liu">Kefang Liu</name><name sortKey="Liu, William J" sort="Liu, William J" uniqKey="Liu W" first="William J." last="Liu">William J. Liu</name><name sortKey="Lu, Qiong" sort="Lu, Qiong" uniqKey="Lu Q" first="Qiong" last="Lu">Qiong Lu</name><name sortKey="Qi, Jianxun" sort="Qi, Jianxun" uniqKey="Qi J" first="Jianxun" last="Qi">Jianxun Qi</name><name sortKey="Wang, Liang" sort="Wang, Liang" uniqKey="Wang L" first="Liang" last="Wang">Liang Wang</name><name sortKey="Yue, Can" sort="Yue, Can" uniqKey="Yue C" first="Can" last="Yue">Can Yue</name><name sortKey="Yue, Can" sort="Yue, Can" uniqKey="Yue C" first="Can" last="Yue">Can Yue</name><name sortKey="Zhang, Di" sort="Zhang, Di" uniqKey="Zhang D" first="Di" last="Zhang">Di Zhang</name></country><country name="Singapour"><noRegion><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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